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分類:導(dǎo)師信息 來(lái)源:中國(guó)考研網(wǎng) 2016-07-19 相關(guān)院校:中國(guó)藥科大學(xué)
金亮,男,1975年9月9日出生,教授,博士生導(dǎo)師。2006年畢業(yè)于中國(guó)藥科大學(xué)微生物與生化藥學(xué)專業(yè),獲博士學(xué)位,后留校任講師;2010年5月晉升為副教授;2010年7月至2013年12月,在美國(guó)希望之城國(guó)家醫(yī)學(xué)中心(National Medical Center)從事博士后研究工作;2014年1月被中國(guó)藥科大學(xué)特聘為教授。近5年來(lái)主持國(guó)家‘863’計(jì)劃項(xiàng)目1項(xiàng)(立項(xiàng)),國(guó)家自然科學(xué)基金面上項(xiàng)目1項(xiàng),國(guó)家自然科學(xué)基金青年基金1項(xiàng),江蘇省杰出青年基金1項(xiàng),中央高;A(chǔ)科研基金2項(xiàng),并作為主要負(fù)責(zé)人(第二負(fù)責(zé)人)主持美國(guó)NIH基金項(xiàng)目(R01,125萬(wàn)美金)1項(xiàng)。近年在國(guó)際權(quán)威雜志發(fā)表了30多篇SCI收錄研究論文,包括Proc Natl Acad Sci USA,The journal of immunology,Stem Cells Dev,Endocrine-Related Cancer,Vaccine等雜志。其中以第一作者發(fā)表SCI論文8篇,累計(jì)影響因子超過(guò)40。
研究方向:1胰腺干細(xì)胞的篩選與分化
2脂肪干細(xì)胞的分化與應(yīng)用
3腫瘤干細(xì)胞生物學(xué)
4重組蛋白及多肽類藥物研究
近5年主要科研成果:
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項(xiàng)目名稱
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項(xiàng)目性質(zhì)及來(lái)源
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胰腺干細(xì)胞的篩選與應(yīng)用研究
T1DM免疫調(diào)節(jié)肽P277功能優(yōu)化及誘發(fā)AS副作用的逆向調(diào)控
miR-26a靶向TET酶調(diào)控胰腺干細(xì)胞分化的作用及機(jī)制研究
miR-26a 靶向TET酶在胰腺成體干細(xì)胞分化過(guò)程中的作用及機(jī)制研究
一種具有抗動(dòng)脈粥樣硬化和抗糖尿病雙功能蛋白的分子定向改造
P277肽的內(nèi)部表位解析及其副作用逆轉(zhuǎn)
Ex vivo differentiation and expansion of adult pancreatic colony-forming units.
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國(guó)家863計(jì)劃項(xiàng)目
國(guó)家自然科學(xué)基金面上項(xiàng)目
江蘇省杰出青年基金
中央高;鸾艹鋈瞬乓龑(dǎo)項(xiàng)目
國(guó)家自然科學(xué)基金青年基金
中央高;
美國(guó)NIH基金項(xiàng)目
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300萬(wàn)
80萬(wàn)
100萬(wàn)
20萬(wàn)
17.5萬(wàn)
3萬(wàn)
125萬(wàn)美金
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2015
2013
2015
2014.1
2008
2010.1
2013
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2017
2016
2017
2014.12
2010
2010.12
2017
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第一作者論文:
1.Liang Jin, Tao Feng, Hung Ping Shih, Ricardo Zerda, Angela Luo, Jasper Hsu, Alborz Mahdavi, Maike Sander, David A. Tirrell, Arthur D. Riggs, and Hsun Teresa Ku*. Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel. Proc Natl Acad Sci USA; 2013, 110 (10) : 3907-3912, (IF:10.583).
2.Xianghui Fu, Liang Jin, Xichun Wang, Angela Luo, Junkai Hu, Xianwu Zheng, Walter M. Tsark, Arthur D. Riggs, H. Teresa Ku*. Wendong Huang; MiR-26a targets TET enzymes and is regulated during pancreatic cell differentiation. Proc Natl Acad Sci USA; 2013, 110 (44): 17892-17897, (Co-first author, IF: 10.583).
3.Liang Jin, Tao Feng, Ricardo Zerda, Ching-Cheng Chen, Arthur D. Riggs and Hsun Teresa Ku*. In vitro multi-lineage differentiation and self-renewal of single pancreatic colony-forming cells from adult C57Bl/6 mice; Stem Cells Dev; 2014, 23 (8): 899-909, (IF:4.67).
4.Liang Jin,Tao Feng, Jing Chai, Nadiah Ghazalli, Dan Gao, Ricardo Zerda, Zhuo Li,Jasper Hsu, Alborz Mahdavi, David A. Tirrell, Arthur D. Riggs,and Hsun Teresa Ku*. Colony-forming progenitor cells in the postnatal mouse liver and pancreas give rise to morphologically distinct insulin-expressing colonies in 3D cultures. Rev Diabet stud; 2014, 11(1):35-50, (IF:2.94).
5.Jin Liang, Zhu Aihua, Wang Yu, Lu Yong Liu Jingjing*. HSP65 serves as an immunogenic carrier for a diabetogenic peptide P277 inducing anti-inflammatory immune response in NOD mice by nasal administration. Vaccine; 2010, 28: 3312-33172, (IF:3.492).
6.Liang Jin, Aihua Zhu, Yu Wang, Qingmei Chen, Qiyan Xiong, Jianping Li, Yunxiao Sun, Taiming Li, Jie Wu, and Jingjing Liu*. A Th1 recognized peptide P277, when tandem repeated, induces a Th2 cytokine burst and toward effective vaccines against autoimmune diabetes in NOD mice. The journal of immunology; 2008, 180 (1): 58 – 63, (IF:5.79).
7.Jin Liang, Zhu aihua, Wang Yu, Liu JingJing*. Enhanced immunogenicity of peptide P277 by heat shock protein HSP65 vector carrying tandem repeats of P277 to prevent type 1 diabetes in NOD mice. Experimental and Clinical Endocrinology & Diabetes; 2008, 116 (9):1-8, (IF:1.555).
8.Jin Liang, Wang Yu, Xiong Qiyan, Chen Qingmei, Li Jianping, Zhu Aihua, Cao Rongyue, Wu Jie, Liu Jingjing Long-lasting specific antibodies against p277 induced by mucosal administration of p277 repeat sequences carried by Hsp65 in the absence of adjuvants. Vaccine; 2007 25: 2043-2050, (IF:3.492).
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