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分類:導師信息 來源:中國考研網 2016-07-13 相關院校:中國藥科大學
楊杰,女,博士,副教授。生于1982年8月。
2000.9—2004.7中國藥科大學中藥學專業(本科)學士
2004.9—2009.7中國藥科大學生藥學(碩博連讀)博士
2009.9-至今中國藥科大學中藥分析教研室,2012年5月晉升副教授。
一直從事中藥及其制劑的質量控制、中藥藥效物質基礎等方面的研究。工作3年來,主持國家自然科學基金2項;江蘇省自然科學基金、教育部博士點基金等科研項目5項,并參與國家科技重大專項等項目的研究。以第一作者或通訊作者發表論文10余篇,在中藥現代化研究領域中具有較強的科研積累。
研究方向及相關課題:
1、現代中藥分析
課題資助:(1)國家科技重大專項:中藥材質量標準研究(批準號:2009ZX09308-04,主要參與者)
2、中藥藥效物質基礎及質量控制
課題資助:(1)國家自然科學基金:翻白草中科羅索酸與所含三萜類成分協同調控巨噬細胞極化穩態系統抗2型糖尿病有效成分群的發現(批準號:81102763,主持)
(2)國家自然科學基金:丹參地上部位調控巨噬細胞極化穩態抗動脈粥樣硬化的物質基礎及作用機制研究(批準號:81373919,主持)
(3)教育部博士點基金:從巨噬細胞極化途徑探討民間藥物翻白草總萜酮部位抗2型糖尿病的物質基礎及作用機制(批準號:No.20100096120004,主持)
(4)江蘇省自然科學基金:山綠茶抗非酒精性脂肪肝有效成分群的發現及其效應機制(批準號:BK2011627,主持)
(5)國家自然科學基金:不同有效成分群組合效應研究山綠茶抗非酒精性脂肪肝藥效物質基礎及效應成分分析(批準號:81073039,參與)
(6)中央高校基本科研業務費專項基金:基于代謝組學探討山綠茶不同有效成分群抗非酒精性脂肪肝的效應關系及效應機制(批準號:JKQ2009008,主持)
(7)天然藥物活性組分與藥效國家重點實驗室優秀青年學者基金:基于多維液質聯用技術研究山綠茶抗NAFLD有效成分群的體內過程及其資源的發掘(批準號:JKGQ201117,主持)
研究成果
1.Hong Chen,Jie Yang (Co- first author), Qin Zhang, Li-Hong Chen, Qiang Wang*. Corosolic Acid Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Regulating the Nuclear Factor-κB Signaling Pathway and Inhibiting Monocyte Chemoattractant Protein-1 Expression. Circulation Journal. 76(4):995-1003,2012
2.Hong Chen, Qin Zhang, Xiaoming Wang, Jie Yang * (Co-corresponding author) and Qiang Wang*,Qualitative Analysis and Simultaneous Quantification of Phenolic Compounds in the Aerial Parts of Salvia miltiorrhiza by HPLC-DAD and ESI/MSn, Phytochemical Analysis, 22:247-257,2011
3.Jie Yang,Fang Lv, Xiao-qing Chen, Wei-xi Cui, Li-hong Chen, Xiao-dong Wen*, Qiang Wang*, Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/ electrospray ionization mass spectrometry.Journal of pharmaceutical and biomedical analysis 77:21-28,2013.
4.Jie Yang, Xiao-dong Wen, Bei-xi Jia, Qian Mao, Qiang Wang*, Mao-xiang Lai. Quality evaluation of Potentilla discolor by high-performance liquid chromatography coupled with diode detection and electrospray ionization tandem mass spectrometry. Phytochemical Analysis,22(6)547-554,2011
5.Jie Yang, Hong Chen, Li Zhang, Qiang Wang*, Mao-Xiang Lai. Anti-diabetic effect of standardized extract ofPotentilla discolorBungeand identification of its active components. Drug Development Research,71:127-132,2010
6.Rong-Hua Ma, Jie Yang (Co- first author),Lian-Wen Qi, Gui-ZhongXin, Chong-Zhi Wang, Chun-Su Yuan, Xiao-Dong Wen*, Ping Li*. In vivo microdialysis with LC–MS for analysis of spinosin and its interaction with cyclosporin A in rat brain, blood and bile. Journal of Pharmaceutical and Biomedical Analysis, 62: 22-29, 2012
7.Xiao-Dong Wen, Jie Yang (Co- first author), Rong-Hua Ma, Wen Gao, Lian-Wen Qi, Ping Li, Brent A. Bauer, Guang-Jian Du, Zhiyu Zhang, Jacqueline Somogyi, Chong-Zhi Wang, Chun-Su Yuan*, Analysis of Panaxnotoginsengmetabolites in rat bile by liquid chromatography-quadrupole time-of-flight mass spectrometry with microdialysis sampling, Journal of Chromatography B, 895-896:162-168, 2012.
8.Li Zhang, Jie Yang (Co- first author), Xiao-qing Chen, Zanke, Xiao-dong Wen, Qiang Wang*, Mao-xiang Lai. Antidiabetic and antioxidant effects of extracts from Potentilla discolor Bunge on diabetic rats induced by high fat diet and streptozotocin. Journal of ethnopharmacology, 132(2):518-524,2010
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